(a) (b) (c)

The relationship between the delta expressions and the p values estimated using

densities fitted for three randomly selected genes from the letrozole drug data.

e ZMIZ2. (b) The gene ATP10B. (c) The gene ARHGAP2B.

e 6.34 shows the correlation between the raw delta expressions

estimated delta expressions from the Gamma density models

ed for the delta expressions of these three genes. It can be seen

correlation coefficients were all very significant. The correlation

ues were less than 1.0e−5. This indicates that fitting a Gamma

unction to the delta expressions for a gene is appropriate for

ting the delta expression significance and hence investigating the

ression bimodality.

(a) (b) (c)

The correlation between the raw delta expressions and the estimated delta

from the Gamma density models fitted to the raw delta expressions for three

elected genes from the letrozole drug data. (a) The gene ZMIZ2. (b) The gene

c) The gene ARHGAP2B.

lso interesting to examine the whole pattern of a Gamma density

estimated for the delta expressions for all genes in the letrozole

set. Figure 6.35 shows the distribution of the estimation of errors